Ready Stock Acide folique Vitamine B9 et vitamine Bc et vitamine M

Modèle NO .: HEA451856M Mode d'utilisation: Pour administration par voie orale Forme: liquide liquide Technologie pharmaceutique: Synthèse chimique Marque et origine: Guyenne, France Emballage: 10 AMPS / Tray/Box Échantillon: Norme de qualité acceptable: GMP / Who GMP / Euro GMP Marque: Guyenne Origine: France Application: Médecine interne État: Liquide Type: Produits biologiques Nom: Spécifications de l'acide folique: 10mg / Ml MOQ: 1 boîte Délai de livraison: 7 jours Durée de conservation: 36 mois Spécification: GMP / WHO GMP / EURO GMP Code SH: 3004909090 Noms
Identificateurs
PropriétésParmacologie

Folic acid
IUPAC name (2S)-2-[[4-[(2-Amino-4-oxo-1H-pteridine6-yl)methylamino]benzoyl]amino]pentanedioic acid
Other names N-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid; pteroyl-L-glutamic acid; Vitamin B9; Vitamin Bc; Vitamin M; Folacin
CAS Number	59-30-3
ChEBI	CHEBI:27470
ChEMBL	ChEMBL1622
ChemSpider	5815
DrugBank	DB00158
IUPHAR/BPS	4563
Jmol interactive 3D	Image
KEGG	C00504
PubChem	6037
RTECS number	LP5425000
UNII	935E97BOY8
Chemical formula	C19H19N7O6
Molar mass	441.40 g·mol?1
Appearance	yellow-orange crystalline powder
Melting point	250 °C (482 °F; 523 K) (decomposition)
Solubility in water	1.6 mg/L (25 °C)
log P	-2.5
Acidity (pKa)	1st: 4.65, 2nd: 6.75, 3rd: 9.00
ATC code	B03BB01

L'acide folique ou l'acide folique est une vitamine B et une période; Il est également appelé vitamine M, vitamine B9, vitamine Bc, et l'acide folklorique, l'acide pteroyl-L-glutamique et le ptéroyl-L-glutamate et la période;
Les fabricants de suppléments alimentaires utilisent souvent le terme folate pour quelque chose de différent de l'acide folique «pur»: en chimie, le folate se réfère à l'ion déprotoné et à l'acide folique à la molécule neutre - qui coexistent tous deux dans l'eau et la période; L'Union internationale de chimie pure et appliquée et l'Union internationale de la biochimie et de la biologie moléculaire déclarent que l'acide folique et folique sont les synonymes préférés pour le pteroylglutamate et l'acide pteroylglutamique, respectivement, et période;
La vitamine B9 est essentielle pour de nombreuses fonctions corporelles et une période; Les humains ne peuvent pas synthétiser les folates de novo et demi; Par conséquent, l'acide folique doit être alimenté par l'alimentation pour répondre à ses besoins quotidiens et à sa période; Le corps humain a besoin de folate pour synthétiser l'ADN, réparer l'ADN et l'ADN méthylate ainsi que pour agir comme cofacteur dans certaines réactions biologiques et une période; Il est particulièrement important d'aider à la division et à la croissance cellulaires rapides, comme dans la petite enfance et la grossesse et la période; Les enfants et les adultes ont tous deux besoin de folate pour produire des globules rouges sains et prévenir l'anémie et la période;
Un manque de folates alimentaires peut entraîner une carence en folate et une période; Un manque complet de folate alimentaire prend des mois avant que la déficience ne se développe car les individus normaux ont environ 500-20 000 microgrammes et lpar; Μg & rpar; De folate dans les magasins corporels et la période; Cette déficience peut entraîner de nombreux problèmes de santé, le plus notable étant les défauts des tubes neuraux dans le développement d'embryons - un défaut de naissance relativement rare affectant 300 000 & lpar; 0 & période; 2 & percnt; & rpar; Les naissances à l'échelle mondiale chaque année et 3 000 grossesses aux États-Unis chaque année et période; Les symptômes communs de la carence en folate comprennent la diarrhée, l'anémie macrocytaire avec faiblesse ou essoufflement, les lésions nerveuses avec faiblesse et l'engourdissement des membres et la neuropathie périphérique, les complications de la grossesse, la confusion mentale, l'oubli ou d'autres déficits cognitifs, la dépression mentale, la langue folle ou enflée, Ulcères peptiques ou buccaux, maux de tête, palpitations cardiaques, irritabilité et troubles du comportement et période; Les faibles niveaux de folate peuvent également entraîner une accumulation et une période d'homocystéine; Les faibles niveaux de folate ont été associés à des cancers et à une période spécifiques; Cependant, il n'est pas clair si la consommation recommandée et lpar; ou plus élevé; Des quantités d'acide folique - provenant d'aliments ou de suppléments - peuvent réduire le risque de cancer chez certaines personnes et par période;

1 Health effects Pregnancy Adequate folate intake during the preconception period (which is the time right before and just after a woman becomes pregnant) helps protect against a number of congenital malformations, including neural tube defects, which are the most notable birth defects that occur from folate insufficiency. Neural tube defects are severe abnormalities of the central nervous system that develop in embryos during the first few weeks of pregnancy resulting in malformations of the spine, skull, and brain; the most common neural tube defects are spina bifida and anencephaly. The risk of neural tube defects is significantly reduced when supplemental folic acid is consumed in addition to a healthy diet before conception and during the first month after conception.Supplementation with folic acid has also been shown to reduce the risk of congenital heart defects, cleft lips, limb defects, and urinary tract anomalies. Folate deficiency during pregnancy may also increase the risk of preterm delivery, infant low birth weight and fetal growth retardation, as well as increasing homocysteine level in the blood, which may lead to spontaneous abortion and pregnancy complications, such as placental abruption and pre-eclampsia. Women who could become pregnant are advised to eat foods fortified with folic acid or take supplements in addition to eating folate-rich foods to reduce the risk of serious birth defects. Some have suggested that all non-pregnant women take 400 micrograms of synthetic folic acid daily from fortified foods or supplements to ensure they have adequate folic acid intake, even in case of unplanned pregnancies.  Failure of post-translational methylation of the cytoskeleton, required for differentiation has been implicated in neural tube defects. Approximately 85% of women in an urban Irish study reported using folic acid supplements before they become pregnant, but only 18% used enough folic acid supplements to meet the current folic acid requirements due, it is reported, to socio-economic challenges. Folic acid supplements may also protect the fetus against disease when the mother is battling a disease or taking medications or smoking during pregnancy. It also contributes to oocyte maturation, implantation, placentation, in addition to the general effects of folic acid and pregnancy. Therefore, it is necessary to receive sufficient amounts through the diet to avoid subfertility. There is growing concern worldwide that prenatal high folic acid in the presence of low vitamin B12 causes epigenetic changes in the unborn predisposing them to metabolic syndromes, central adiposity and adult diseases such as Type 2 diabetes. Another active area of research and concern is that either too much or too little folic acid in utero causes epigenetic changes to the brain leading to autism spectrum disorders. Epidemiologic studies have been demonstrating a correlation between maternal folic supplementation with folic acid and increased risk for asthma and respiratory diseases in children. However, a systematic review and meta-analysis did not confirm such findings and recommends additional studies to verify the hypothesis.   Fertility Folate is necessary for fertility in both men and women. It contributes to spermatogenesis. Therefore, it is necessary to receive sufficient amounts through the diet to avoid subfertility. Also, polymorphisms in genes of enzymes involved in folate metabolism could be one reason for fertility complications in some women with unexplained infertility. Heart disease Taking folic acid does not reduce cardiovascular disease even though it reduces homocysteine levels. Folic acid supplements consumed before and during pregnancy may reduce the risk of heart defects in infants. Stroke Folic acid appears to reduce the risk of stroke, which may be due to the role folate plays in regulating homocysteine concentration. The reviews indicate the risk of stroke appears to be reduced only in some individuals, but a definite recommendation regarding supplementation beyond the current RDA has not been established for stroke prevention. Observed stroke reduction is consistent with the reduction in pulse pressure produced by folate supplementation of 5 mg per day, since hypertension is a key risk factor for stroke. Folic supplements are inexpensive and relatively safe to use, which is why stroke or hyperhomocysteinemia patients are encouraged to consume daily B vitamins including folic acid. Cancer Folic acid supplementation does not appear to affect the rate of cancer. Diets high in folate are associated with decreased risk of colorectal cancer; some studies show the association is stronger for folate from foods alone than for folate from foods and supplements, One broad cancer screening trial reported a potential harmful effect of too much folate intake on breast cancer risk, suggesting routine folate supplementation should not be recommended as a breast cancer preventive. Most research studies indicate that dietary folate intake does not significantly increase or decrease the risk of prostate cancer. Antifolate chemotherapy Folate is important for cells and tissues that rapidly divide. Cancer cells divide rapidly, and drugs that interfere with folate metabolism are used to treat cancer.    Psychological Some evidence links a shortage of folate with depression. Limited evidence from randomised controlled trials showed using folic acid in addition to SSRIs may have benefits. Research at the University of York and Hull York Medical School has found a link between depression and low levels of folate. One study by the same team involved 15,315 subjects. However, the evidence is probably[weasel words] too limited at present for this to be a routine treatment recommendation.[according to whom?] Folic acid supplementation affects noradrenaline and serotonin receptors within the brain, which could be the cause of folic acid's possible ability to act as an antidepressant. The exact mechanisms involved in the development of schizophrenia and depression are not entirely clear, but the bioactive folate, methyltetrahydrofolate (5-MTHF), a direct target of methyl donors like S-adenosyl methionine (SAMe), recycles the inactive dihydrobiopterin (BH2) into tetrahydrobiopterin (BH4), the necessary cofactor in various steps of monoamine synthesis, including that of dopamine. BH4 serves a regulatory role in monoamine neurotransmission and is required to mediate the actions of most antidepressants. 5-MTHF also plays both direct & indirect roles in DNA methylation, NO2 synthesis, and one-carbon metabolism. Macular degeneration A substudy of the Women's Antioxidant and Folic Acid Cardiovascular Study published in 2009 reported use of a nutritional supplement containing folic acid, pyridoxine, and cyanocobalamin decreased the risk of developing age-related macular degeneration by 34.7%. Folic acid, B12 and iron There is a complex interaction between folic acid, vitamin B12 and iron. A deficiency of one may be "masked" by excess of another so the three must always be in balance. Toxicity The risk of toxicity from folic acid is low, because folate is a water-soluble vitamin and is regularly removed from the body through urine. One potential issue associated with high dosages of folic acid is that it has a masking effect on the diagnosis of pernicious anaemia (vitamin B12 deficiency), and a variety of concerns[clarification needed] of potential negative impacts on health. 2 Rôles biologiques DNA and cell division Folate is necessary for the production and maintenance of new cells, for DNA synthesis and RNA synthesis, and for preventing changes to DNA, and, thus, for preventing cancer. It is especially important during periods of frequent cell division and growth, such as infancy and pregnancy. Folate is needed to carry one-carbon groups for methylation reactions and nucleic acid synthesis (the most notable one being thymine, but also purine bases). Thus, folate deficiency hinders DNA synthesis and cell division, affecting hematopoietic cells and neoplasms the most because of their greater frequency of cell division. RNA transcription, and subsequent protein synthesis, are less affected by folate deficiency, as the mRNA can be recycled and used again (as opposed to DNA synthesis, where a new genomic copy must be created). Since folate deficiency limits cell division, erythropoiesis, production of red blood cells, is hindered and leads to megaloblastic anemia, which is characterized by large immature red blood cells. This pathology results from persistently thwarted attempts at normal DNA replication, DNA repair, and cell division, and produces abnormally large red cells called megaloblasts (and hypersegmented neutrophils) with abundant cytoplasm capable of RNA and protein synthesis, but with clumping and fragmentation of nuclear chromatin. Some of these large cells, although immature (reticulocytes), are released early from the marrow in an attempt to compensate for the anemia. Both adults and children need folate to make normal red and white blood cells and prevent anemia. Deficiency of folate in pregnant women has been implicated in neural tube defects (NTD); therefore, many developed countries have implemented mandatory folic acid fortification in cereals, etc. NTDs occur early in pregnancy (first month), therefore women must have abundant folate upon conception. Folate is required to make red blood cells and white blood cells and folate deficiency may lead to anemia, which causes fatigue, weakness and inability to concentrate. Metabolism of folic acid to recycle homocysteine into methionine In the form of a series of tetrahydrofolate (THF) compounds, folate derivatives are substrates in a number of single-carbon-transfer reactions, and also are involved in the synthesis of dTMP (2′-deoxythymidine-5′-phosphate) from dUMP (2′-deoxyuridine-5′-phosphate). It is a substrate for an important reaction that involves vitamin B12 and it is necessary for the synthesis of DNA, and so required for all dividing cells. The pathway leading to the formation of tetrahydrofolate (FH4) begins when folic acid (F) is reduced to dihydrofolate (DHF) (FH2), which is then reduced to THF. Dihydrofolate reductase catalyses the last step.Vitamin B3 in the form of NADPH is a necessary cofactor for both steps of the synthesis. Thus, hydride molecules are transferred from NADPH to the C6 position of the pteridine ring to reduce folic acid to THF. Methylene-THF (CH2FH4) is formed from THF by the addition of a methylene bridge from one of three carbon donors: formate, serine, or glycine. Methyl tetrahydrofolate (CH3-THF, or methyl-THF) can be made from methylene-THF by reduction of the methylene group with NADPH. Folate metabolism Conversion to biologically active derivatives All the biological functions of folic acid are performed by tetrahydrofolate and other derivatives. Their biological availability to the body depends upon dihydrofolate reductase action in the liver. This action is unusually slow in humans, being less than 2% of that in rats. Moreover, in contrast to rats, an almost-5-fold variation in the activity of this enzyme exists between humans. Due to this low activity, it has been suggested this limits the conversion of folic acid into its biologically active forms "when folic acid is consumed at levels higher than the Tolerable Upper Intake Level (1 mg/d for adults)." National Institutes of Health & lpar; US & rpar; Exigences nutritionnelles et taux de mortalité par jour et par jour; AgeInfants & lpar; RDI & rpar; Infants et jeunes adultes et adultes; RDI & Rpar; Adult & Lpar; UL & rpar; Femmes enceintes et femmes âgées; Femmes enceintes et femmes diplômées; Lactating women & lpar; RDI & rpar; Lactating women & lpar; UL & rpar; 0-6 months 65 None set - - - - - - 7-12 months 80 None set - - - - - - 1-3 years - - 150 300 - - - - 4-8 years - - 200 400 - - -  - 9-13 years - - 300 600 - - - - 14-18 - - 400 800 600 800 500 800 19+ - - 400 1000 600 1000 500 1000 Groupes de Produits : Produits anti-âge autres produits Stock prêt pour la peau blanchissant la vitamine C avec l'injection de collagène Contacter Maintenant Supplément nutritionnel de soin de peau Vitamine C + Injection de collagène Contacter Maintenant Stock prêt pour la peau 500mg + 175mg de vitamine C + injection de collagène Contacter Maintenant Injection de blanchiment de la peau Vitamine C + Injection de collagène en stock Contacter Maintenant Produits phares Comprimés à 200 mg de chlorhydrate d'amiodarone de haute qualitéCrème de monobenzone de peau blancheMédecine générale Omeprazole 20mg Injection pour Gastrohelcosis et Stomach AcidMédicament général Ceftriaxone Sodium InjectionReady Stock Skin Whitening anti-âge Vitamine C InjectionTablette OEM 500mg ParacétamolHaute qualité 500mg Capsules rigides Amoxicillin (amoxycilline)Meilleur et bas prix Ceftriaxone Sodium Injection CeftriaxoneMeilleure qualité Omega 3 Deep Sea Softgel Capsule Huile de poissonArtemisinine antipaludique curative approuvée par la FDAMédecine traitant une lésion cérébrale Injection de Citicoline SodiumProtease Alpha Chymolase pour œdème inflammatoireMédecine générale Medroxyprogesterone Actate InjectionAmikacin Injection Médicaments généraux MédicamentsBlanchiment de la peau Gsh Soins personnels Glutathion InjectionBody Slimming Fitness Perdre du poids Perte de poids L-Carnitine Injection2.0g / 5ml Fournisseurs de haute qualité Salicylate de sodium, Chimique pharmaceutique, Maladie de peau en Chine Accueil tous les produits Détails de Contact Plan du site Copyright © 2024 fr.nsantibiotics.comTous droits réservés.